Nonstop flights from Charlotte to Key West
American Airlines flies this route 2 to 3 times a day.
CLTCharlotte Douglas International
739 mi · 15 flights a week
EYWKey West International
When they leave
Charlotte time10:45a4:19pFirst departure 10:45 AM, last 4:19 PM
One morning flight at 10:45 AM, then two in the afternoon, 1:59 PM to 4:19 PM.
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Schedules last checked Sep 22, 2026. Times are local.
Flying from Charlotte to Key West
American Airlines is the only airline flying nonstop from Charlotte to Key West, 2 to 3 times a day on the Embraer 175 and Airbus A319.
Flights run every day of the week, 3 on Sundays and 2 on the other days. The first arrival in Key West is at 12:55 PM and the last at 6:44 PM. The flight covers 739 miles.
Flying back, Key West to Charlotte has 15 nonstop flights a week.
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Schedules as of Oct 9, 2026.