Nonstop flights from Jacksonville to St. Louis

Southwest Airlines flies this route 1 to 2 times a day.

JAXJacksonville International

753 mi · 9 flights a week

STLSt. Louis Lambert International

JAXSTL

When they leave

Jacksonville time

6:15a6:50pFirst departure 6:15 AM, last 6:50 PM

Three in the morning, 6:15 AM to 6:40 AM, then two in the afternoon, 12:25 PM to 2:00 PM, then one evening flight at 6:50 PM.

Every flight

Earliest first

6:15 AM→7:25 AMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
6:25 AM→7:35 AMSouthwest AirlinesBoeing 737Sun
6:40 AM→7:45 AMSouthwest AirlinesBoeing 737 MAX 8Sat
12:25 PM→1:30 PMSouthwest AirlinesBoeing 737 MAX 8Sat
2:00 PM→3:10 PMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri
6:50 PM→7:55 PMSouthwest AirlinesBoeing 737Sun

Schedules last checked Sep 21, 2026. Times are local.

Flying from Jacksonville to St. Louis

Southwest Airlines is the only airline flying nonstop from Jacksonville to St. Louis, 1 to 2 times a day on the Boeing 737 MAX 8, Boeing 737 and Boeing 737-700.

Flights run every day of the week, 2 on Saturdays and Sundays and 1 on the other days. The first arrival in St. Louis is at 7:25 AM and the last at 7:55 PM. The flight covers 753 miles.

Flying back, St. Louis to Jacksonville has 9 nonstop flights a week.

Return flights

St. Louis to JacksonvilleView

Find the cheapest day to fly from Jacksonville to St. Louis.

Schedules as of Oct 9, 2026.