Nonstop flights from St. Louis to Columbus
Southwest Airlines flies this route 1 to 2 times a day.
STLSt. Louis Lambert International
409 mi · 11 flights a week
CMHJohn Glenn Columbus International
When they leave
St. Louis time10:05a6:50pFirst departure 10:05 AM, last 6:50 PM
Two in the morning, 10:05 AM to 10:10 AM, then one evening flight at 6:50 PM.
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Earliest first
Schedules last checked Sep 21, 2026. Times are local.
Flying from St. Louis to Columbus
Southwest Airlines is the only airline flying nonstop from St. Louis to Columbus, 1 to 2 times a day on the Boeing 737-700 and Boeing 737 MAX 8.
There are 1 or 2 flights every day of the week. The first arrival in Columbus is at 12:25 PM and the last at 9:10 PM. The flight covers 409 miles.
Flying back, Columbus to St. Louis has 13 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.