Nonstop flights from St. Louis to San Diego
Southwest Airlines flies this route daily.
STLSt. Louis Lambert International
1,555 mi · 7 flights a week
SANSan Diego International
When they leave
St. Louis time8:25a2:15pFirst departure 8:25 AM, last 2:15 PM
One morning flight at 8:25 AM, then one afternoon flight at 2:15 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from St. Louis to San Diego
Southwest Airlines is the only airline flying nonstop from St. Louis to San Diego, daily on the Boeing 737 and Boeing 737 MAX 8.
The first arrival in San Diego is at 10:10 AM and the last at 3:55 PM. The flight covers 1,555 miles.
More from St. Louis
Find the cheapest day to fly from St. Louis to San Diego.
Schedules as of Oct 9, 2026.