Nonstop flights from Charlotte to Des Moines
American Airlines flies this route 2 to 3 times a day.
CLTCharlotte Douglas International
814 mi · 20 flights a week
DSMDes Moines International
When they leave
Charlotte time11:03a5:20pFirst departure 11:03 AM, last 5:20 PM
One morning flight at 11:03 AM, then one afternoon flight at 2:50 PM, then one evening flight at 5:20 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Charlotte to Des Moines
American Airlines is the only airline flying nonstop from Charlotte to Des Moines, 2 to 3 times a day on the Airbus A319 and CRJ 900.
There are 2 or 3 flights every day of the week. The first arrival in Des Moines is at 12:24 PM and the last at 6:41 PM. The flight covers 814 miles.
Flying back, Des Moines to Charlotte has 19 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.