Nonstop flights from Des Moines to Detroit
Delta Air Lines flies this route 3 times a day.
DSMDes Moines International
531 mi · 21 flights a week
DTWDetroit Metropolitan Wayne County
When they leave
Des Moines time6:00a5:30pFirst departure 6:00 AM, last 5:30 PM
Two in the morning, 6:00 AM to 10:23 AM, then one evening flight at 5:30 PM. Every flight runs daily.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Des Moines to Detroit
Delta Air Lines is the only airline flying nonstop from Des Moines to Detroit, 3 times a day on the CRJ 700 and CRJ 900.
The first arrival in Detroit is at 8:50 AM and the last at 8:22 PM. The flight covers 531 miles.
Flying back, Detroit to Des Moines has 21 nonstop flights a week.
Return flights
More from Des Moines
Find the cheapest day to fly from Des Moines to Detroit.
Schedules as of Oct 9, 2026.