Nonstop flights from Des Moines to Chicago

Southwest Airlines flies this route twice a day.

DSMDes Moines International

305 mi · 14 flights a week

MDWChicago Midway International

DSMMDW

When they leave

Des Moines time

5:40a3:50pFirst departure 5:40 AM, last 3:50 PM

Two in the morning, 5:40 AM to 6:10 AM, then three in the afternoon, 12:10 PM to 3:50 PM.

Every flight

Earliest first

5:40 AM→7:00 AMSouthwest AirlinesBoeing 737 MAX 8Mon, Thu, Fri
6:10 AM→7:30 AMSouthwest AirlinesBoeing 737-700Tue, Wed, Sat, Sun
12:10 PM→1:30 PMSouthwest AirlinesBoeing 737 MAX 8Sat
2:40 PM→4:00 PMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
3:50 PM→5:10 PMSouthwest AirlinesBoeing 737Mon, Thu, Fri
3:50 PM→5:10 PMSouthwest AirlinesBoeing 737-700Sun

Schedules last checked Sep 19, 2026. Times are local.

Flying from Des Moines to Chicago

Southwest Airlines is the only airline flying nonstop from Des Moines to Chicago, twice a day on the Boeing 737 MAX 8, Boeing 737-700 and Boeing 737.

The first arrival in Chicago is at 7:00 AM and the last at 5:10 PM. The flight covers 305 miles.

Flying back, Chicago to Des Moines has 12 nonstop flights a week. From Des Moines, O'Hare (ORD) is the other Chicago area airport with nonstop flights, 58 a week.

Return flights

Chicago to Des MoinesView

Every Chicago airport

All Des Moines to Chicago flightsView

Find the cheapest day to fly from Des Moines to Chicago.

Schedules as of Oct 9, 2026.