Nonstop flights from Detroit to Greenville
Delta Air Lines flies this route 2 to 3 times a day.
DTWDetroit Metropolitan Wayne County
510 mi · 20 flights a week
GSPGreenville-Spartanburg International
When they leave
Detroit time8:25a7:45pFirst departure 8:25 AM, last 7:45 PM
Two in the morning, 8:25 AM to 10:10 AM, then one afternoon flight at 4:22 PM, then one evening flight at 7:45 PM.
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Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Detroit to Greenville
Delta Air Lines is the only airline flying nonstop from Detroit to Greenville, 2 to 3 times a day on the Boeing 717, CRJ 700 and CRJ 900.
There are 2 or 3 flights every day of the week. The first arrival in Greenville is at 10:15 AM and the last at 9:26 PM. The flight covers 510 miles.
Flying back, Greenville to Detroit has 20 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.