Nonstop flights from Chicago to Greenville
2 airlines fly this route, with up to 7 flights a day.
ORDChicago O'Hare International
578 mi · 49 flights a week
GSPGreenville-Spartanburg International
When they leave
Chicago time6:30a8:24pFirst departure 6:30 AM, last 8:24 PM
Three in the morning, 6:30 AM to 10:25 AM, then two in the afternoon, 1:55 PM to 3:05 PM, then two in the evening, 5:59 PM to 8:24 PM.
Every flight
Earliest first
Schedules last checked Sep 8, 2026. Times are local.
Flying from Chicago to Greenville
United Airlines flies most often, 4 times a day on the Embraer 175, Boeing 737 and CRJ 700. American Airlines flies 3 times a day on the Embraer 175.
There are 7 flights every day of the week. The first arrival in Greenville is at 9:36 AM and the last at 11:25 PM. The flight covers 578 miles.
Flying back, Greenville to Chicago has 49 nonstop flights a week.
Return flights
More from Chicago
Find the cheapest day to fly from Chicago to Greenville.
Schedules as of Oct 9, 2026.