Nonstop flights from Orlando to Louisville

Southwest Airlines flies this route 1 to 3 times a day.

MCOOrlando International

721 mi · 13 flights a week

SDFLouisville Muhammad Ali International

MCOSDF

When they leave

Orlando time

8:50a7:45pFirst departure 8:50 AM, last 7:45 PM

Two in the morning, 8:50 AM to 9:00 AM, then one afternoon flight at 2:10 PM, then one evening flight at 7:45 PM.

Every flight

Earliest first

8:50 AM→11:00 AMSouthwest AirlinesBoeing 737-700Sun
9:00 AM→11:10 AMSouthwest AirlinesBoeing 737 MAX 8Mon, Thu, Fri
9:00 AM→11:10 AMSouthwest AirlinesBoeing 737-700Sat
9:00 AM→11:10 AMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
2:10 PM→4:15 PMSouthwest AirlinesBoeing 737Sat
7:45 PM→9:55 PMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri, Sat, Sun

Schedules last checked Sep 20, 2026. Times are local.

Flying from Orlando to Louisville

Southwest Airlines is the only airline flying nonstop from Orlando to Louisville, 1 to 3 times a day on the Boeing 737-700, Boeing 737 MAX 8 and Boeing 737.

Flights run every day of the week, from 1 on Tuesdays and Wednesdays to 3 on Saturdays. The first arrival in Louisville is at 11:00 AM and the last at 9:55 PM. The flight covers 721 miles.

Flying back, Louisville to Orlando has 11 nonstop flights a week.