Nonstop flights from Chicago to Buffalo

2 airlines fly this route.

ORDChicago O'Hare International

472 mi · 38 flights a week

BUFBuffalo Niagara International

ORDBUF

When they leave

Chicago time

6:49a9:10pFirst departure 6:49 AM, last 9:10 PM

Three in the morning, 6:49 AM to 10:25 AM, then two in the afternoon, 2:07 PM to 2:19 PM, then two in the evening, 6:15 PM to 9:10 PM.

Every flight

Earliest first

6:49 AM→9:28 AMUnited AirlinesBoeing 737Mon, Wed, Thu, Fri, Sun
6:50 AM→9:39 AMAmerican AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri, Sun
10:25 AM→1:16 PMUnited AirlinesCRJ 700Mon, Wed, Thu, Fri, Sun
2:07 PM→4:56 PMUnited AirlinesBoeing 737Mon, Wed, Thu, Fri, Sun
2:19 PM→5:04 PMAmerican AirlinesAirbus A319Mon, Tue, Wed, Thu, Fri, Sun
6:15 PM→9:07 PMUnited AirlinesAirbus A319Mon, Wed, Thu, Fri, Sun
9:10 PM→12:02 AM⁺¹American AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri, Sun

Schedules last checked Sep 20, 2026. Times are local.

Flying from Chicago to Buffalo

United Airlines flies most often, 20 times a week on the Boeing 737, Airbus A319 and CRJ 700. American Airlines flies 18 times a week on the Embraer 175 and Airbus A319.

Flights run every day except Saturdays, up to 7 a day. The first arrival in Buffalo is at 9:28 AM and the last at 12:02 AM the next day. The flight covers 472 miles.

Flying back, Buffalo to Chicago has 49 nonstop flights a week. Midway (MDW) also has nonstop flights to Buffalo, 20 a week.