Nonstop flights from Charlotte to Buffalo
American Airlines flies this route 4 times a day.
CLTCharlotte Douglas International
546 mi · 28 flights a week
BUFBuffalo Niagara International
When they leave
Charlotte time10:22a8:10pFirst departure 10:22 AM, last 8:10 PM
One morning flight at 10:22 AM, then two in the afternoon, 2:15 PM to 4:15 PM, then one evening flight at 8:10 PM. Every flight runs daily.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Charlotte to Buffalo
American Airlines is the only airline flying nonstop from Charlotte to Buffalo, 4 times a day on the Boeing 737 and Boeing 737 MAX 8.
The first arrival in Buffalo is at 12:06 PM and the last at 9:55 PM. The flight covers 546 miles.
Flying back, Buffalo to Charlotte has 28 nonstop flights a week.
Return flights
More from Charlotte
Find the cheapest day to fly from Charlotte to Buffalo.
Schedules as of Oct 9, 2026.