Nonstop flights from Panama City to Mexico City

2 airlines fly this route, with up to 8 flights a day.

PTYPanama City Tocumen International Airport Panama

1,498 mi · 50 flights a week · about 3h 50m

MEXMexico City International Airport Benito Juárez

PTYMEX

When they leave

Panama City time

9:29a10:13pFirst departure 9:29 AM, last 10:13 PM

Two in the morning, 9:29 AM to 11:53 AM, then two in the afternoon, 2:50 PM to 4:27 PM, then four in the evening, 7:12 PM to 10:13 PM.

Every flight

Earliest first

9:29 AM→12:10 PMCopa AirlinesBoeing 737 MAX 8 · 3h 41mDaily
11:53 AM→2:30 PMCopa AirlinesBoeing 737-800 · 3h 37mDaily
2:50 PM→5:40 PMAeroméxicoUntil Jan 19, 2027Embraer 190 · 3h 50mDaily
4:27 PM→7:20 PMCopa AirlinesBoeing 737-800 · 3h 53mDaily
7:12 PM→10:05 PMCopa AirlinesBoeing 737-800 · 3h 53mDaily
7:32 PM→10:25 PMCopa AirlinesBoeing 737 · 3h 53mMon, Tue, Wed, Sat, Sun
9:28 PM→12:15 AM⁺¹Copa AirlinesBoeing 737-800 · 3h 47mDaily
10:13 PM→1:00 AM⁺¹Copa AirlinesBoeing 737-800 · 3h 47mTue, Thu, Fri

Schedules last checked Oct 2, 2026. Times are local.

Flying from Panama City to Mexico City

Copa Airlines flies most often, 6 to 7 times a day on the Boeing 737-800, Boeing 737 and Boeing 737 MAX 8. Aeroméxico flies daily on the Embraer 190.

Flights run every day of the week, 8 on Tuesdays and 7 on the other days. The first arrival in Mexico City is at 12:10 PM and the last at 1:00 AM the next day. The flight covers 1,498 miles, and scheduled flight times run from 3h 37m to 3h 53m.

Aeroméxico flies it until Jan 19, 2027.

Flying back, Mexico City to Panama City has 49 nonstop flights a week.

Return flights

Mexico City to Panama CityView

Find the cheapest day to fly from Panama City to Mexico City.

Schedules as of Oct 9, 2026.