Nonstop flights from Mexico City to Panama City
2 airlines fly this route, with up to 7 flights a day.
MEXMexico City International Airport Benito Juárez
1,498 mi · 49 flights a week
PTYPanama City Tocumen International Airport Panama
When they leave
Mexico City time12:25a3:30pFirst departure 12:25 AM, last 3:30 PM
Three overnight flights, 12:25 AM to 2:10 AM, then three in the morning, 5:50 AM to 9:50 AM, then two in the afternoon, 1:10 PM to 3:30 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Mexico City to Panama City
Copa Airlines flies most often, 6 times a day on the Boeing 737-800 and Boeing 737. Aeroméxico flies daily on the Embraer 190.
There are 7 flights every day of the week. The first arrival in Panama City is at 5:06 AM and the last at 8:14 PM. The flight covers 1,498 miles.
Flying back, Panama City to Mexico City has 50 nonstop flights a week.
Return flights
More from Mexico City
Find the cheapest day to fly from Mexico City to Panama City.
Schedules as of Oct 9, 2026.