Nonstop flights from Louisville to Chicago

2 airlines fly this route, with up to 9 flights a day.

SDFLouisville Muhammad Ali International

286 mi · 62 flights a week

ORDChicago O'Hare International

SDFORD

When they leave

Louisville time

5:10a7:18pFirst departure 5:10 AM, last 7:18 PM

Seven in the morning, 5:10 AM to 11:05 AM, then one afternoon flight at 1:50 PM, then three in the evening, 5:45 PM to 7:18 PM.

Every flight

Earliest first

5:10 AM→5:48 AMUnited AirlinesCRJ 700Sun
5:15 AM→5:55 AMUnited AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri
6:28 AM→7:15 AMAmerican AirlinesEmbraer 175Daily
7:10 AM→7:50 AMUnited AirlinesEmbraer 175Daily
9:00 AM→9:41 AMUnited AirlinesEmbraer 175Daily
10:23 AM→11:03 AMUnited AirlinesEmbraer 175Daily
11:05 AM→11:44 AMAmerican AirlinesEmbraer 170Daily
1:50 PM→2:30 PMUnited AirlinesCRJ 700Daily
5:45 PM→6:36 PMUnited AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri, Sat
5:45 PM→6:34 PMUnited AirlinesCRJ 700Sun
6:30 PM→7:24 PMAmerican AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri, Sun
7:18 PM→8:12 PMAmerican AirlinesEmbraer 175Sat

Schedules last checked Sep 20, 2026. Times are local.

Flying from Louisville to Chicago

United Airlines flies most often, 5 to 6 times a day on the Embraer 175 and CRJ 700. American Airlines flies 3 times a day on the Embraer 175 and Embraer 170.

There are 8 or 9 flights every day of the week. The first arrival in Chicago is at 5:48 AM and the last at 8:12 PM. The flight covers 286 miles.

Flying back, Chicago to Louisville has 62 nonstop flights a week. From Louisville, Midway (MDW) is the other Chicago area airport with nonstop flights, 20 a week.