Nonstop flights from St. Louis to Panama City

Southwest Airlines flies this route 9 times a week until Oct 31, then again from Nov 21.

STLSt. Louis Lambert International

634 mi · 9 flights a week

ECPPanama City Northwest Florida Beaches International

STLECP

When they leave

St. Louis time

10:10a7:15pFirst departure 10:10 AM, last 7:15 PM

Two in the morning, 10:10 AM to 11:30 AM, then four in the afternoon, 12:20 PM to 4:20 PM, then one evening flight at 7:15 PM.

Every flight

Earliest first

10:10 AM→12:00 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737 MAX 8Sat
11:30 AM→1:15 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737 MAX 8Sun
12:20 PM→2:05 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737 MAX 8Sat
1:55 PM→3:40 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737 MAX 8Tue, Wed
2:50 PM→4:35 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737-700Mon, Fri
4:20 PM→6:05 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737-700Sat
7:15 PM→9:00 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737-700Sun

Schedules last checked Sep 19, 2026. Times are local.

Flying from St. Louis to Panama City

Southwest Airlines is the only airline flying nonstop from St. Louis to Panama City, 9 times a week on the Boeing 737 MAX 8 and Boeing 737-700.

Flights run every day except Thursdays, up to 3 a day. The first arrival in Panama City is at 12:00 PM and the last at 9:00 PM. The flight covers 634 miles.

Flying back, Panama City to St. Louis has 10 nonstop flights a week.

Return flights

Panama City to St. LouisView

More to Panama City

Find the cheapest day to fly from St. Louis to Panama City.

Schedules as of Oct 9, 2026.