Nonstop flights from Panama City to St. Louis

Southwest Airlines flies this route 1 to 3 times a day until Oct 31, then again from Nov 21.

ECPPanama City Northwest Florida Beaches International

634 mi · 10 flights a week

STLSt. Louis Lambert International

ECPSTL

When they leave

Panama City time

5:50a5:10pFirst departure 5:50 AM, last 5:10 PM

Three in the morning, 5:50 AM to 11:45 AM, then two in the afternoon, 1:40 PM to 3:45 PM, then one evening flight at 5:10 PM.

Every flight

Earliest first

5:50 AM→7:40 AMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737Sun
7:15 AM→9:05 AMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737Sat
11:45 AM→1:30 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737Sat
1:40 PM→3:25 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737-700Sat
3:45 PM→5:30 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737-700Tue, Wed, Sun
5:10 PM→6:55 PMSouthwest AirlinesUntil Oct 31, back Nov 21Boeing 737-700Mon, Thu, Fri

Schedules last checked Sep 19, 2026. Times are local.

Flying from Panama City to St. Louis

Southwest Airlines is the only airline flying nonstop from Panama City to St. Louis, 1 to 3 times a day on the Boeing 737 and Boeing 737-700.

Flights run every day of the week, from 1 on Mondays, Tuesdays, Wednesdays, Thursdays and Fridays to 3 on Saturdays. The first arrival in St. Louis is at 7:40 AM and the last at 6:55 PM. The flight covers 634 miles.

Flying back, St. Louis to Panama City has 9 nonstop flights a week.

Return flights

St. Louis to Panama CityView

More to St. Louis

Find the cheapest day to fly from Panama City to St. Louis.

Schedules as of Oct 9, 2026.