Nonstop flights from Knoxville to Chicago

3 airlines fly from Knoxville (TYS) to 2 Chicago airports (ORD and MDW), with up to 9 flights a day.

TYSORD

Routes

2 airport pairs

TYS to ORDMcGhee Tyson to Chicago O'Hare8 a day
TYS to MDWMcGhee Tyson to Chicago Midway4 a week

When they leave

Knoxville time

7:00a6:52pFirst departure 7:00 AM, last 6:52 PM

Five in the morning, 7:00 AM to 11:40 AM, then four in the afternoon, 1:02 PM to 1:58 PM, then two in the evening, 6:02 PM to 6:52 PM.

Every flight

Earliest first

7:00 AM→7:56 AMTYS to ORDUnited AirlinesBoeing 737Daily
7:34 AM→8:45 AMTYS to ORDAmerican AirlinesEmbraer 170Daily
10:40 AM→11:44 AMTYS to ORDUnited AirlinesCRJ 700Mon, Thu, Fri
10:40 AM→11:44 AMTYS to ORDUnited AirlinesCRJ 700Tue, Wed, Sat, Sun
11:34 AM→12:06 PMTYS to MDWAllegiant AirUntil Nov 29Airbus A320Mon
11:40 AM→12:44 PMTYS to ORDAmerican AirlinesCRJ 700Daily
1:02 PM→1:34 PMTYS to MDWAllegiant AirUntil Nov 29Airbus A320Fri
1:21 PM→2:23 PMTYS to ORDAmerican AirlinesEmbraer 170Daily
1:53 PM→2:54 PMTYS to ORDUnited AirlinesCRJ 700Daily
1:58 PM→2:37 PMTYS to MDWAllegiant AirUntil Nov 29Airbus A320Sun
1:58 PM→2:37 PMTYS to MDWAllegiant AirUntil Nov 29Airbus A320Wed
6:02 PM→7:00 PMTYS to ORDUnited AirlinesAirbus A319Daily
6:52 PM→8:04 PMTYS to ORDAmerican AirlinesCRJ 700Daily

Schedules last checked Sep 22, 2026. Times are local.

Flying from Knoxville to Chicago

American Airlines flies 4 times a day on the CRJ 700 and Embraer 170. United Airlines flies 4 times a day on the CRJ 700, Airbus A319 and Boeing 737. Allegiant Air flies 4 times a week on the Airbus A320.

There are 8 or 9 flights every day of the week. The first arrival in Chicago is at 7:56 AM and the last at 8:04 PM.

TYS to ORD is the busiest airport pair, with 56 flights a week, then TYS to MDW with 4.

On TYS to MDW, Allegiant Air flies it until Nov 29.

Flying back, Chicago to Knoxville has 60 nonstop flights a week.

Return flights

Chicago to KnoxvilleView

Find the cheapest day to fly from Knoxville to Chicago.

Schedules as of Oct 9, 2026.