Nonstop flights from Knoxville to Chicago
2 airlines fly this route, with up to 8 flights a day.
TYSKnoxville McGhee Tyson
475 mi · 56 flights a week
ORDChicago O'Hare International
When they leave
Knoxville time7:00a6:52pFirst departure 7:00 AM, last 6:52 PM
Four in the morning, 7:00 AM to 11:40 AM, then two in the afternoon, 1:21 PM to 1:53 PM, then two in the evening, 6:02 PM to 6:52 PM.
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Schedules last checked Sep 20, 2026. Times are local.
Flying from Knoxville to Chicago
American Airlines flies 4 times a day on the CRJ 700 and Embraer 170. United Airlines flies 4 times a day on the CRJ 700, Airbus A319 and Boeing 737.
There are 8 flights every day of the week. The first arrival in Chicago is at 7:56 AM and the last at 8:04 PM. The flight covers 475 miles.
Flying back, Chicago to Knoxville has 56 nonstop flights a week.
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Schedules as of Oct 9, 2026.