Nonstop flights from Knoxville to Houston
United Airlines flies this route 3 times a day.
TYSKnoxville McGhee Tyson
771 mi · 21 flights a week
IAHHouston George Bush Intercontinental
When they leave
Knoxville time7:15a3:40pFirst departure 7:15 AM, last 3:40 PM
One morning flight at 7:15 AM, then two in the afternoon, 2:21 PM to 3:40 PM. Every flight runs daily.
Every flight
Earliest first
Schedules last checked Sep 21, 2026. Times are local.
Flying from Knoxville to Houston
United Airlines is the only airline flying nonstop from Knoxville to Houston, 3 times a day on the Embraer 175.
The first arrival in Houston is at 8:44 AM and the last at 5:09 PM. The flight covers 771 miles.
Flying back, Houston to Knoxville has 19 nonstop flights a week.
Return flights
Every Houston airport
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Find the cheapest day to fly from Knoxville to Houston.
Schedules as of Oct 9, 2026.