Nonstop flights from Chicago to Knoxville
2 airlines fly this route, with up to 8 flights a day.
ORDChicago O'Hare International
475 mi · 56 flights a week
TYSKnoxville McGhee Tyson
When they leave
Chicago time6:59a7:29pFirst departure 6:59 AM, last 7:29 PM
Four in the morning, 6:59 AM to 10:29 AM, then two in the afternoon, 2:10 PM to 3:30 PM, then two in the evening, 6:06 PM to 7:29 PM.
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Schedules last checked Sep 20, 2026. Times are local.
Flying from Chicago to Knoxville
American Airlines flies 4 times a day on the CRJ 700 and Embraer 170. United Airlines flies 4 times a day on the CRJ 700, Airbus A319 and Boeing 737.
There are 8 flights every day of the week. The first arrival in Knoxville is at 9:57 AM and the last at 10:17 PM. The flight covers 475 miles.
Flying back, Knoxville to Chicago has 56 nonstop flights a week.
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Schedules as of Oct 9, 2026.