Nonstop flights from Charlotte to Knoxville
American Airlines flies this route 7 to 8 times a day.
CLTCharlotte Douglas International
176 mi · 55 flights a week
TYSKnoxville McGhee Tyson
When they leave
Charlotte time8:27a9:40pFirst departure 8:27 AM, last 9:40 PM
Two in the morning, 8:27 AM to 10:25 AM, then three in the afternoon, 12:15 PM to 4:18 PM, then three in the evening, 5:41 PM to 9:40 PM.
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Schedules last checked Sep 22, 2026. Times are local.
Flying from Charlotte to Knoxville
American Airlines is the only airline flying nonstop from Charlotte to Knoxville, 7 to 8 times a day on the Embraer ERJ-145, CRJ 700 and CRJ 900.
There are 7 or 8 flights every day of the week. The first arrival in Knoxville is at 9:43 AM and the last at 10:58 PM. The flight covers 176 miles.
Flying back, Knoxville to Charlotte has 55 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.