Nonstop flights from Panama City to Santo Domingo

Copa Airlines flies this route 4 to 6 times a day.

PTYPanama City Tocumen International Airport Panama

918 mi · 36 flights a week

SDQSanto Domingo Las Américas International

PTYSDQ

When they leave

Panama City time

7:24a10:55pFirst departure 7:24 AM, last 10:55 PM

Three in the morning, 7:24 AM to 9:42 AM, then one afternoon flight at 12:44 PM, then two in the evening, 7:26 PM to 10:55 PM.

Every flight

Earliest first

7:24 AM→10:55 AMCopa AirlinesBoeing 737Mon, Wed, Thu, Fri, Sat
8:11 AM→11:42 AMCopa AirlinesBoeing 737 MAX 8Daily
9:42 AM→1:13 PMCopa AirlinesBoeing 737 MAX 9Daily
12:44 PM→4:15 PMCopa AirlinesBoeing 737Daily
7:26 PM→10:56 PMCopa AirlinesBoeing 737Daily
10:55 PM→2:25 AM⁺¹Copa AirlinesBoeing 737Mon, Wed, Sat

Schedules last checked Sep 19, 2026. Times are local.

Flying from Panama City to Santo Domingo

Copa Airlines is the only airline flying nonstop from Panama City to Santo Domingo, 4 to 6 times a day on the Boeing 737, Boeing 737 MAX 8 and Boeing 737 MAX 9.

Flights run every day of the week, from 4 on Tuesdays and Sundays to 6 on Mondays, Wednesdays and Saturdays. The first arrival in Santo Domingo is at 10:55 AM and the last at 2:25 AM the next day. The flight covers 918 miles.

Flying back, Santo Domingo to Panama City has 34 nonstop flights a week.

Return flights

Santo Domingo to Panama CityView

More to Santo Domingo

Find the cheapest day to fly from Panama City to Santo Domingo.

Schedules as of Oct 9, 2026.