Nonstop flights from Santo Domingo to Panama City

Copa Airlines flies this route 4 to 6 times a day.

SDQSanto Domingo Las Américas International

918 mi · 34 flights a week

PTYPanama City Tocumen International Airport Panama

SDQPTY

When they leave

Santo Domingo time

6:07a6:42pFirst departure 6:07 AM, last 6:42 PM

Two in the morning, 6:07 AM to 8:48 AM, then three in the afternoon, 12:13 PM to 2:17 PM, then one evening flight at 6:42 PM.

Every flight

Earliest first

6:07 AM→7:39 AMCopa AirlinesBoeing 737Tue, Thu, Sun
8:48 AM→10:20 AMCopa AirlinesBoeing 737-800Daily
12:13 PM→1:45 PMCopa AirlinesBoeing 737-800Mon, Thu, Sat
12:43 PM→2:15 PMCopa AirlinesBoeing 737 MAX 8Daily
2:17 PM→3:49 PMCopa AirlinesBoeing 737-800Daily
6:42 PM→8:14 PMCopa AirlinesBoeing 737-800Daily

Schedules last checked Sep 19, 2026. Times are local.

Flying from Santo Domingo to Panama City

Copa Airlines is the only airline flying nonstop from Santo Domingo to Panama City, 4 to 6 times a day on the Boeing 737-800, Boeing 737 and Boeing 737 MAX 8.

Flights run every day of the week, from 4 on Wednesdays and Fridays to 6 on Thursdays. The first arrival in Panama City is at 7:39 AM and the last at 8:14 PM. The flight covers 918 miles.

Flying back, Panama City to Santo Domingo has 36 nonstop flights a week.

Return flights

Panama City to Santo DomingoView

More to Panama City

Find the cheapest day to fly from Santo Domingo to Panama City.

Schedules as of Oct 9, 2026.