Nonstop flights from Des Moines to Los Angeles
American Airlines flies this route daily.
DSMDes Moines International
1,445 mi · 7 flights a week
LAXLos Angeles International
When they leave
Des Moines time6:48p6:48pDeparts 6:48 PM
One departure, at 6:48 PM. It runs daily.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Des Moines to Los Angeles
American Airlines is the only airline flying nonstop from Des Moines to Los Angeles, daily on the Embraer 175.
The flight covers 1,445 miles.
Flying back, Los Angeles to Des Moines has 7 nonstop flights a week.
Return flights
More from Des Moines
Find the cheapest day to fly from Des Moines to Los Angeles.
Schedules as of Oct 9, 2026.