Nonstop flights from Orlando to Knoxville

2 airlines fly this route, with up to 2 flights a day.

MCOOrlando International

533 mi · 9 flights a week

TYSKnoxville McGhee Tyson

MCOTYS

When they leave

Orlando time

11:25a8:57pFirst departure 11:25 AM, last 8:57 PM

One morning flight at 11:25 AM, then three in the afternoon, 1:00 PM to 3:25 PM, then two in the evening, 5:23 PM to 8:57 PM.

Every flight

Earliest first

11:25 AM→1:05 PMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
1:00 PM→2:40 PMSouthwest AirlinesBoeing 737 MAX 8Sat
1:20 PM→3:00 PMSouthwest AirlinesBoeing 737-700Sun
3:25 PM→5:10 PMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri
5:23 PM→7:05 PMAllegiant AirAirbus A320Fri
8:57 PM→10:44 PMAllegiant AirAirbus A320Mon

Schedules last checked Sep 21, 2026. Times are local.

Flying from Orlando to Knoxville

Southwest Airlines flies most often, daily on the Boeing 737 MAX 8 and Boeing 737-700. Allegiant Air flies on Mondays and Fridays with the Airbus A320.

Flights run every day of the week, 2 on Mondays and Fridays and 1 on the other days. The first arrival in Knoxville is at 1:05 PM and the last at 10:44 PM. The flight covers 533 miles.

Flying back, Knoxville to Orlando has 9 nonstop flights a week.

Return flights

Knoxville to OrlandoView

Find the cheapest day to fly from Orlando to Knoxville.

Schedules as of Oct 9, 2026.